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Structural and Antigenic Variation among Diverse Clade 2 H5N1 Viruses

27 Sept 2013

Abstract excerpt

Antigenic variation among circulating H5N1 highly pathogenic avian influenza A viruses mandates the continuous production of strain-specific pre-pandemic vaccine candidates and represents a significant challenge for pandemic preparedness. Here we assessed the structural, antigenic and receptor-binding properties of three H5N1 HPAI virus hemagglutinins, which were recently selected by the WHO as vaccine candidates...

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PMID: 24086467
DOI: 10.1371/journal.pone.0075209

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