The transcriptome of follicular cells: biological insights and clinical implications for the treatment of infertility

Abstract excerpt

BACKGROUND: Oocyte maturation is under strict regulatory control, not only from intrinsic cellular processes, but also extrinsic influences. While the oocyte is directly connected to the surrounding cumulus cells (CCs) via a network of gap junctions facilitating communication and exchange of molecules, it is also influenced by the greater follicular environment. In order to produce an oocyte capable of...

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