In vitro activity of temocillin against multidrug-resistant clinical isolates of Escherichia coli, Klebsiella spp. and Enterobacter spp., and evaluation of high-level temocillin resistance as a diagnostic marker for OXA-48 carbapenemase

Abstract excerpt

Sir, Temocillin is a narrow-spectrum penicillin active primarily against Enterobacteriaceae and resistant to hydrolysis by penicillinases, extended-spectrum β-lactamases (ESBLs), and AmpC enzymes.1 It has been shown also to retain some activity in vitro against Enterobacteriaceae with KPC-type carbapenemases,2,3 although not against bacteria with OXA-48-like non-metalloenzymes or the metalloenzymes (including...

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