Article
Combined effects of icam-1 single-nucleotide polymorphisms and environmental carcinogens on oral cancer susceptibility and clinicopathologic development.
PloS one - 1 Jan 2013
Lin Chiao-Wen, Chuang Chun-Yi, Tang Chih-Hsin, Chang Junn-Liang, Lee Liang-Ming, Lee Wei-Jiunn, Chow Jyh-Ming, Yang Shun-Fa, Chien Ming-Hsien
Abstract excerpt
BACKGROUND: In Taiwan, oral cancer has causally been associated with environmental carcinogens. Intercellular adhesion molecule (ICAM)-1, a cell adhesion molecule with a key role in inflammation and immunosurveillance, was implicated in carcinogenesis by facilitating instability in the tumor environment. The current study explored the combined effect of ICAM-1 gene polymorphisms and exposure to environmental...
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