Article
Chronic insulin exposure does not cause insulin resistance but is associated with chemo-resistance in colon cancer cells.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 Feb 2014
Baricevic I, Roberts D L, Renehan A G
Abstract excerpt
Insulin resistance is an adaptive process in insulin-sensitive tissues characterised by reduced insulin receptor (IR) and insulin-receptor substrate (IRS)-1 expression, increased IRS-1 serine phosphorylation and attenuated downstream signalling. We tested whether this molecular phenotype prevails in cancer cells after long-term exposure to insulin. We characterised expression of IR-related molecules, IRS-1...
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