Article
Electrophysiological phenotype in the LQTS mutations Y111C and R518X in the KCNQ1 gene.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Nov 2013
Diamant Ulla-Britt, Vahedi Farzad, Winbo Annika, Rydberg Annika, Stattin Eva-Lena, Jensen Steen M, Bergfeldt Lennart
Abstract excerpt
Long QT syndrome is the prototypical disorder of ventricular repolarization (VR), and a genotype-phenotype relation is postulated. Furthermore, although increased VR heterogeneity (dispersion) may be important in the arrhythmogenicity in long QT syndrome, this hypothesis has not been evaluated in humans and cannot be tested by conventional electrocardiography. In contrast, vectorcardiography allows assessment of...
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