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Article

The impact of neurochemical mediators on antidepressant effectiveness.

ACS chemical neuroscience - 18 Sept 2013

Metzner Richard J

Abstract excerpt

Despite marked differences in the psychobiological profiles of depressed patients, clinical research has not supported selection of antidepressant (AD) medications based on neurochemistry. Prescribers have been advised to start all patients on the same class of ADs and then switch or combine them until benefit is achieved. New research may transform this practice. By matching clinical moderators to neurochemical...

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Identifiers

PMID: 24047106
DOI: 10.1021/cn400135e
PMCID: PMC3778421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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