Article
Cell-surface Notch1 expression identifies a primitive phenotype within CD34+ CD38- haematopoietic cells.
European journal of haematology - 1 Jan 2014
Portillo Virginia, Chadwick Nicholas, Lloyd Ruth, Jackson Dean, Buckle Anne-Marie
Abstract excerpt
OBJECTIVE: Notch signalling has been implicated in haematopoietic stem cell self-renewal. Although several studies have tested the effect of activating or inhibiting the Notch signalling pathway in stem cells, no study has yet determined the functional differences associated with expressing Notch1. The aims of this study were to characterise the expression of human cell-surface Notch1 in cord blood (CB) CD34(+)...
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