Article
Identification of key clinical phenotypes of breast cancer using a reduced panel of protein biomarkers.
British journal of cancer - 1 Oct 2013
Green A R, Powe D G, Rakha E A, Soria D, Lemetre C, Nolan C C, Barros F F T, Macmillan R D, Garibaldi J M, Ball G R, Ellis I O
Abstract excerpt
BACKGROUND: Breast cancer is a heterogeneous disease characterised by complex molecular alterations underlying the varied behaviour and response to therapy. However, translation of cancer genetic profiling for use in routine clinical practice remains elusive or prohibitively expensive. As an alternative, immunohistochemical analysis applied to routinely processed tissue samples could be used to identify distinct...
Topics
- Biomarkers, Tumor
- Breast Neoplasms
- Female
- Gene Expression Profiling
- Humans
- Immunohistochemistry
- Neoplasm Proteins
- Phenotype
- Prognosis
- Receptor, ErbB-2
- Receptors, Estrogen