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Article

Hypomethylation of Alu elements in post-menopausal women with osteoporosis.

PloS one - 1 Jan 2013

Jintaridth Pornrutsami, Tungtrongchitr Rungsunn, Preutthipan Sangchai, Mutirangura Apiwat

Abstract excerpt

A decrease in genomic methylation commonly occurs in aging cells; however, whether this epigenetic modification leads to age-related phenotypes has not been evaluated. Alu elements are the major interspersed repetitive DNA elements in humans that lose DNA methylation in aging individuals. Alu demethylation in blood cells starts at approximately 40 years of age, and the degree of Alu hypomethylation increases with...

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Source

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Identifiers

PMID: 23990903
DOI: 10.1371/journal.pone.0070386
PMCID: PMC3749148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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