Article
High rate of cytomegalovirus drug resistance among patients receiving preemptive antiviral treatment after haploidentical stem cell transplantation.
The Journal of infectious diseases - 15 Feb 2014
Shmueli Einat, Or Reuven, Shapira Michael Y, Resnick Igor B, Caplan Orit, Bdolah-Abram Tali, Wolf Dana G
Abstract excerpt
We examined the rate, clinical impact, and risk factors of cytomegalovirus (CMV) drug resistance in 561 patients who underwent 616 hematopoietic stem cell transplantations (HSCTs) over 5 years. Drug resistance was exclusively identified in haploidentical (haplo)-HSCT recipients receiving preemptive therapy, among whom the rate was 14.5%. Resistance appeared after prolonged treatment (median, 70 days), was...
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