Article
Effect of malaria transmission reduction by insecticide-treated bed nets (ITNs) on the genetic diversity of Plasmodium falciparum merozoite surface protein (MSP-1) and circumsporozoite (CSP) in western Kenya.
Malaria journal - 27 Aug 2013
Kariuki Simon K, Njunge James, Muia Ann, Muluvi Geofrey, Gatei Wangeci, Ter Kuile Feiko, Terlouw Dianne J, Hawley William A, Phillips-Howard Penelope A, Nahlen Bernard L, Lindblade Kim A, Hamel Mary J, Slutsker Laurence, Shi Ya Ping
Abstract excerpt
BACKGROUND: Although several studies have investigated the impact of reduced malaria transmission due to insecticide-treated bed nets (ITNs) on the patterns of morbidity and mortality, there is limited information on their effect on parasite diversity. METHODS: Sequencing was used to investigate the effect of ITNs on polymorphisms in two genes encoding leading Plasmodium falciparum vaccine candidate antigens, the...
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