Article
An odorant-binding protein required for suppression of sweet taste by bitter chemicals.
Neuron - 21 Aug 2013
Jeong Yong Taek, Shim Jaewon, Oh So Ra, Yoon Hong In, Kim Chul Hoon, Moon Seok Jun, Montell Craig
Abstract excerpt
Animals often must decide whether or not to consume a diet that contains competing attractive and aversive compounds. Here, using the fruit fly, Drosophila melanogaster, we describe a mechanism that influences this decision. Addition of bitter compounds to sucrose suppressed feeding behavior, and this inhibition depended on an odorant-binding protein (OBP) termed OBP49a. In wild-type flies, bitter compounds...
Topics
- Action Potentials
- Analgesics, Non-Narcotic
- Animals
- Animals, Genetically Modified
- Choice Behavior
- Dose-Response Relationship, Drug
- Drosophila Proteins
- Drosophila melanogaster
- Electrodes
- Food Preferences
- Green Fluorescent Proteins
- Mutation
- Odorants