Article
Increased proliferative background in healthy women with BRCA1/2 haploinsufficiency is associated with high risk for breast cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2013
Nisman Benjamin, Kadouri Luna, Allweis Tanir, Maly Bella, Hamburger Tamar, Gronowitz Simon, Peretz Tamar
Abstract excerpt
Previous studies indicated that BRCA haploinsufficiency was associated with activation of the EGF receptor (EGFR) signaling pathway and increased proliferative activity in mammary epithelial cells of healthy women. We hypothesized that these processes might be reflected in the expression of serologic soluble EGFR (sEGFR) and thymidine kinase 1 (TK1) activity, which signal the initial and final steps of the...
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