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Article

Development of a pharmacokinetic interaction model for co-administration of simvastatin and amlodipine.

Drug metabolism and pharmacokinetics - 1 Jan 2014

Son Hankil, Lee Donghwan, Lim Lay Ahyoung, Jang Seong Bok, Roh Hyerang, Park Kyungsoo

Abstract excerpt

A model for drug interaction between amlodipine and simvastatin was developed using concentration data obtained from a multiple-dose study consisting of single- and co-administration of amlodipine and simvastatin conducted in healthy Koreans. Amlodipine concentrations were assumed to influence the clearance of simvastatin and simvastatin acid, which as well as the oral bioavailability was allowed to vary...

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Identifiers

PMID: 23965645
DOI: 10.2133/dmpk.dmpk-13-rg-053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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