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Article

Cartilage to bone transitions in health and disease.

The Journal of endocrinology - 1 Oct 2013

Staines K A, Pollard A S, McGonnell I M, Farquharson C, Pitsillides A A

Abstract excerpt

Aberrant redeployment of the 'transient' events responsible for bone development and postnatal longitudinal growth has been reported in some diseases in what is otherwise inherently 'stable' cartilage. Lessons may be learnt from the molecular mechanisms underpinning transient chondrocyte differentiation and function, and their application may better identify disease aetiology. Here, we review the current evidence...

Topics

Bone Development
Bone Diseases
Cartilage
Cartilage, Articular
Cell Differentiation
Chondrocytes
Epiphyses
Growth Plate
Humans
Intervertebral Disc Degeneration
Ossification, Heterotopic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Osteoarthritis

Osteogenesis

Phenotype

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Identifiers

PMID: 23959079
DOI: 10.1530/JOE-13-0276
PMCID: PMC3769078

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