Article
A homozygous SLITRK6 nonsense mutation is associated with progressive auditory neuropathy in humans.
The Laryngoscope - 1 Mar 2014
Morlet Thierry, Rabinowitz Mindy R, Looney Liesl R, Riegner Tammy, Greenwood L Ashleigh, Sherman Eric A, Achilly Nathan, Zhu Anni, Yoo Estelle, O'Reilly Robert C, Jinks Robert N, Puffenberger Erik G, Heaps Adam, Morton Holmes, Strauss Kevin A
Abstract excerpt
OBJECTIVES/HYPOTHESIS: SLITRK family proteins control neurite outgrowth and regulate synaptic development. In mice, Slitrk6 plays a role in the survival and innervation of sensory neurons in the inner ear, vestibular apparatus, and retina, and also influences axial eye length. We provide the first detailed description of the auditory phenotype in humans with recessive SLITRK6 deficiency. STUDY DESIGN: Prospective...
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