Article
Exome sequencing and linkage analysis identified tenascin-C (TNC) as a novel causative gene in nonsyndromic hearing loss.
PloS one - 1 Jan 2013
Zhao Yali, Zhao Feifan, Zong Liang, Zhang Peng, Guan Liping, Zhang Jianguo, Wang Dayong, Wang Jing, Chai Wei, Lan Lan, Li Qian, Han Bing, Yang Ling, Jin Xin, Yang Weiyan, Hu Xiaoxiang, Wang Xiaoning, Li Ning, Li Yingrui, Petit Christine, Wang Jun, Wang Huanming Yang Jian, Wang Qiuju
Abstract excerpt
In this study, a five-generation Chinese family (family F013) with progressive autosomal dominant hearing loss was mapped to a critical region spanning 28.54 Mb on chromosome 9q31.3-q34.3 by linkage analysis, which was a novel DFNA locus, assigned as DFNA56. In this interval, there were 398 annotated genes. Then, whole exome sequencing was applied in three patients and one normal individual from this family. Six...
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