Article
The embedding problem for markov models of nucleotide substitution.
PloS one - 1 Jan 2013
Verbyla Klara L, Yap Von Bing, Pahwa Anuj, Shao Yunli, Huttley Gavin A
Abstract excerpt
Continuous-time Markov processes are often used to model the complex natural phenomenon of sequence evolution. To make the process of sequence evolution tractable, simplifying assumptions are often made about the sequence properties and the underlying process. The validity of one such assumption, time-homogeneity, has never been explored. Violations of this assumption can be found by identifying...
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