Combined segregation and linkage analysis of genetic hemochromatosis using affection status, serum iron, and HLA.

Article

Combined segregation and linkage analysis of genetic hemochromatosis using affection status, serum iron, and HLA.

American journal of human genetics - 1 Sept 1990

Borecki I B, Lathrop G M, Bonney G E, Yaouanq J, Rao D C

Abstract excerpt

Characterizing the distribution of parameters of iron metabolism by hemochromatosis genotype remains an important goal vis-à-vis potential screening strategies to identify individuals at genetic risk, since a specific marker to detect the abnormal gene has not been identified as yet. In the present investigation, we analyze serum iron values in ascertained families using a method which incorporates both...

Topics

Age Factors
Female
Genes, Recessive
Genetic Linkage
Genotype
HLA Antigens
Hemochromatosis
Homozygote
Humans
Iron
Male
Models, Genetic

Phenotype

Regression Analysis

Sex Factors

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