Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deletion of arcD in Streptococcus pneumoniae D39 impairs its capsule and attenuates virulence.

Infection and immunity - 1 Oct 2013

Gupta Radha, Yang Jun, Dong Yimin, Swiatlo Edwin, Zhang Jing-Ren, Metzger Dennis W, Bai Guangchun

Abstract excerpt

The arginine deiminase system (ADS) is associated with arginine catabolism and plays a role in virulence of several pathogenic bacteria. In Streptococcus pneumoniae, the ADS genes exist as a locus consisting of arcABCDT. A recent genome-wide mutagenesis approach revealed that both arcD and arcT are potentially essential in a chinchilla otitis media (OM) model. In the present study, we generated ΔarcD, ΔarcT, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Transport Systems
Share to Antiporters

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bacteremia

Share to Bacterial Capsules

Share to Gene Expression Regulation, Bacterial

Share to Otitis Media

Share to Pneumonia, Bacterial

Share to Streptococcus pneumoniae

Source

Open in PubMed Open full text

Identifiers

PMID: 23918778
DOI: 10.1128/IAI.00778-13
PMCID: PMC3811789

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of arcD in Streptococcus pneumoniae D39 impairs its capsule and attenuates virulence.PMID 23918778Read ↗

Genetic requirement for pneumococcal ear infection.Semantic proximity Read ↗

Complete Genome Sequence of Streptococcus pneumoniae Strain ST556, a Multidrug-Resistant Isolate from an Otitis Media PatientSemantic proximity Read ↗

Arginine regulates the mucoid phenotype of hypervirulent Klebsiella pneumoniae.Semantic proximity Read ↗

Characterization of cis- Acting Sites Controlling Arginine Deiminase Gene Expression in Streptococcus gordoniiSemantic proximity Read ↗

Deletion of the Zinc Transporter Lipoprotein AdcAII Causes Hyperencapsulation of Streptococcus pneumoniae Associated with Distinct Alleles of the Type I Restriction-Modification System.Semantic proximity Read ↗

Evaluation of the virulence of a Streptococcus pneumoniae neuraminidase-deficient mutant in nasopharyngeal colonization and development of otitis media in the chinchilla model.Semantic proximity Read ↗

ciaR impacts biofilm formation by regulating an arginine biosynthesis pathway in Streptococcus sanguinis SK36.Semantic proximity Read ↗

The multifaceted proteins MvaT and MvaU, members of the H-NS family, control arginine metabolism, pyocyanin synthesis, and prophage activation in Pseudomonas aeruginosa PAO1.Semantic proximity Read ↗

Structure, Regulation, and Putative Function of the Arginine Deiminase System of<i>Streptococcus suis</i>Semantic proximity Read ↗

The arc operon for anaerobic arginine catabolism in Pseudomonas aeruginosa contains an additional gene, arcD, encoding a membrane protein.Semantic proximity Read ↗

Regions important for the adhesin activity of Moraxella catarrhalis Hag.Semantic proximity Read ↗

Strain-specific virulence phenotypes of Streptococcus pneumoniae assessed using the Chinchilla laniger model of otitis media.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.