Article
An Arabidopsis ATP-dependent, DEAD-box RNA helicase loses activity upon IsoAsp formation but is restored by PROTEIN ISOASPARTYL METHYLTRANSFERASE.
The Plant cell - 1 Jul 2013
Nayak Nihar R, Putnam Andrea A, Addepalli Balasubrahmanyam, Lowenson Jonathan D, Chen Tingsu, Jankowsky Eckhard, Perry Sharyn E, Dinkins Randy D, Limbach Patrick A, Clarke Steven G, Downie A Bruce
Abstract excerpt
Orthodox seeds are capable of withstanding severe dehydration. However, in the dehydrated state, Asn and Asp residues in proteins can convert to succinimide residues that can further react to predominantly form isomerized isoAsp residues upon rehydration (imbibition). IsoAsp residues can impair protein function and can render seeds nonviable, but PROTEIN ISOASPARTYL METHYLTRANSFERASE (PIMT) can initiate isoAsp...
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