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Article

Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1.

Molecular and cellular biology - 1 Oct 2013

Tran Tram Anh, Kinch Lisa, Peña-Llopis Samuel, Kockel Lutz, Grishin Nick, Jiang Huaqi, Brugarolas James

Abstract excerpt

Vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptors are implicated in development and tumorigenesis and dual inhibitors like sunitinib are prescribed for cancer treatment. While mammalian VEGF and PDGF receptors are present in multiple isoforms and hetero...

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Identifiers

PMID: 23878397
DOI: 10.1128/MCB.01570-12
PMCID: PMC3811881

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PVR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23878397-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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