Article
Oral neutrophil transcriptome changes result in a pro-survival phenotype in periodontal diseases.
PloS one - 1 Jan 2013
Lakschevitz Flavia S, Aboodi Guy M, Glogauer Michael
Abstract excerpt
BACKGROUND: Periodontal diseases are inflammatory processes that occur following the influx of neutrophils into the periodontal tissues in response to the subgingival bacterial biofilm. Current literature suggests that while neutrophils are protective and prevent bacterial infections, they also appear to contribute to damage of the periodontal tissues. In the present study we compare the gene expression profile...
Topics
- Apoptosis
- Cell Movement
- Chronic Periodontitis
- Down-Regulation
- Female
- Humans
- Inflammation
- Male
- Middle Aged
- Mouth
- Neutrophils
- Periodontium
- Phenotype
- Proto-Oncogene Proteins c-bcl-2
- Transcriptome
- Up-Regulation