Article
TEM-1 -lactamase as a source of resistance to sulbactam in clinical strains of Acinetobacter baumannii
9 Jul 2013
Abstract excerpt
OBJECTIVES: Sulbactam is well known to have clinically relevant intrinsic activity against Acinetobacter baumannii. Although secondary resistance to this drug has long been reported in acinetobacters, virtually nothing is known about its molecular basis. The aim of this study was to test the hypothesis that β-lactamase TEM-1 is responsible for sulbactam resistance in A. baumannii. METHODS: Seventeen clinical...
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