Article
Metabolomic markers reveal novel pathways of ageing and early development in human populations.
International journal of epidemiology - 1 Aug 2013
Menni Cristina, Kastenmüller Gabriella, Petersen Ann Kristin, Bell Jordana T, Psatha Maria, Tsai Pei-Chien, Gieger Christian, Schulz Holger, Erte Idil, John Sally, Brosnan M Julia, Wilson Scott G, Tsaprouni Loukia, Lim Ee Mun, Stuckey Bronwyn, Deloukas Panos, Mohney Robert, Suhre Karsten, Spector Tim D, Valdes Ana M
Abstract excerpt
BACKGROUND: Human ageing is a complex, multifactorial process and early developmental factors affect health outcomes in old age. METHODS: Metabolomic profiling on fasting blood was carried out in 6055 individuals from the UK. Stepwise regression was performed to identify a panel of independent metabolites which could be used as a surrogate for age. We also investigated the association with birthweight overall and...
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