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Article

Conserved regions of gonococcal TbpB are critical for surface exposure and transferrin iron utilization.

Infection and immunity - 1 Sept 2013

Ostberg Karen L, DeRocco Amanda J, Mistry Shreni D, Dickinson Mary Kathryne, Cornelissen Cynthia Nau

Abstract excerpt

The transferrin-binding proteins TbpA and TbpB enable Neisseria gonorrhoeae to obtain iron from human transferrin. The lipoprotein TbpB facilitates, but is not strictly required for, TbpA-mediated iron acquisition. The goal of the current study was to determine the contribution of two conserved regions within TbpB to the function of this protein. Using site-directed mutagenesis, the first mutation we constructed...

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Identifiers

PMID: 23836816
DOI: 10.1128/IAI.00280-13
PMCID: PMC3754215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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