Article
Cell cycle suppressor proteins are not related to HPV status or clinical outcome in patients with vulvar carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Dec 2013
Lavorato-Rocha André Mourão, Rodrigues Iara Sant'ana, de Melo Maia Beatriz, Stiepcich Mônica Maria Ágata, Baiocchi Glauco, Carvalho Kátia Cândido, Soares Fernando Augusto, Vassallo José, Rocha Rafael Malagoli
Abstract excerpt
Interactions between the cyclin-dependent kinase inhibitors (CDKI) and human papillomavirus (HPV) infection in the pathogenesis of vulvar carcinoma are still incomplete. This study aimed to evaluate the prognostic relevance of these proteins in vulvar cancer. One hundred and thirty-nine patient specimens assembled in a tissue microarray were evaluated for p16, p21, p27, and pRb by immunohistochemistry. HPV status...
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