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Article

Molecular cytogenetic analysis for TFE3 rearrangement in Xp11.2 renal cell carcinoma and alveolar soft part sarcoma: validation and clinical experience with 75 cases.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2014

Hodge Jennelle C, Pearce Kathryn E, Wang Xiaoke, Wiktor Anne E, Oliveira Andre M, Greipp Patricia T

Abstract excerpt

Renal cell carcinoma with TFE3 rearrangement at Xp11.2 is a distinct subtype manifesting an indolent clinical course in children, with recent reports suggesting a more aggressive entity in adults. This subtype is morphologically heterogeneous and can be misclassified as clear cell or papillary renal cell carcinoma. TFE3 is also rearranged in alveolar soft part sarcoma. To aid in diagnosis, a break-apart strategy...

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Topics

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Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, X

Share to Gene Fusion

Share to Gene Rearrangement

Share to Kidney Neoplasms

Share to Oncogene Proteins, Fusion

Share to Translocation, Genetic

Source

Identifiers

PMID: 23828314
DOI: 10.1038/modpathol.2013.83

Genes

ASPSCR1
NONO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular cytogenetic analysis for TFE3 rearrangement in Xp11.2 renal cell carcinoma and alveolar soft part sarcoma: validation and clinical experience with 75 cases.PMID 23828314Read ↗

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