Article
In vitro toxic action potential of anti tuberculosis drugs and their combinations.
Environmental toxicology and pharmacology - 1 Sept 2013
Fatima Riffat, Ashraf Muhammad, Ejaz Sohail, Rasheed Muhammad Adil, Altaf Imran, Afzal Misbah, Batool Zainab, Saleem Umber, Anwar Khaleeq
Abstract excerpt
Tuberculosis (TB) is one of the leading infectious causes of death due to single infectious agent after HIV/AIDS. Rifampicin (RIF), Isoniazid (INH), Ethambutol (EMB), Pyrazinamide (PZA) and/or their combinations are extensively prescribed to treat TB. Despite several therapeutic implications, these drugs also produce several toxic effects at cellular level. MTT assay and Ames test were adopted in this study for...
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