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Article

Disease-associated mutations in CNGB3 promote cytotoxicity in photoreceptor-derived cells.

Molecular vision - 1 Jan 2013

Liu Chunming, Sherpa Tshering, Varnum Michael D

Abstract excerpt

PURPOSE: To determine if achromatopsia associated F525N and T383fsX mutations in the CNGB3 subunit of cone photoreceptor cyclic nucleotide-gated (CNG) channels increases susceptibility to cell death in photoreceptor-derived cells. METHODS: Photoreceptor-derived 661W cells were transfected with cDNA encoding wild-type (WT) CNGA3 subunits plus WT or mutant CNGB3 subunits, and incubated with the membrane-permeable...

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Source

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Identifiers

PMID: 23805033
DOI: 10.1167/13.9.1268
PMCID: PMC3692405

Genes

CNGB3
CNGA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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