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Article

Protein-mediated antagonism between HIV reverse transcriptase ligands nevirapine and MgATP.

Biophysical journal - 18 Jun 2013

Zheng Xunhai, Mueller Geoffrey A, DeRose Eugene F, London Robert E

Abstract excerpt

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) play a central role in the treatment of AIDS, but their mechanisms of action are incompletely understood. The interaction of the NNRTI nevirapine (NVP) with HIV-1 reverse transcriptase (RT) is characterized by a preference for the open conformation of the fingers/thumb subdomains, and a reported variation of three orders of magnitude between the binding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23790378
DOI: 10.1016/j.bpj.2013.04.015
PMCID: PMC3686349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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