Article
Association between TLR4 and TLR9 gene polymorphisms with development of pulmonary tuberculosis in Zahedan, southeastern Iran.
TheScientificWorldJournal - 1 Jan 2013
Jahantigh Danial, Salimi Saeedeh, Alavi-Naini Roya, Emamdadi Abolfazl, Owaysee Osquee Hamid, Farajian Mashhadi Farzaneh
Abstract excerpt
Some evidence suggests that a variety of genetic factors contribute to development of the tuberculosis (TB). TLR4 and TLR9 have been proposed as susceptibility genes for TB. This study was performed in 124 newly diagnosed TB cases and 149 healthy controls in a TB-endemic region of Iran. The TLR4 genes Asp299Gly, Thr399Ile, and TLR9 gene T-1486C polymorphisms were amplified by polymerase chain reaction (PCR) and...
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