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Over‐expression of human cytomegalovirus miR‐US25‐2‐3p downregulates eIF4A1 and inhibits HCMV replication

6 Jun 2013

Abstract excerpt

It has been reported that human cytomegalovirus (HCMV) miR-US25-2 reduces DNA viral replication including HCMV. However, the mechanism remains unknown. In our study, eukaryotic translation initiation factor 4A1 (eIF4A1) was identified to be a direct target of miR-US25-2-3p. Small interfering RNA (siRNA) and miR-US25-2-3p mediated eIF4A1 knockdown experiments revealed that high level of miR-US25-2-3p in MRC-5...

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PMID: 23747307
DOI: 10.1016/j.febslet.2013.05.057

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