Article
A method for accounting for maintenance costs in flux balance analysis improves the prediction of plant cell metabolic phenotypes under stress conditions.
The Plant journal : for cell and molecular biology - 1 Sept 2013
Cheung C Y Maurice, Williams Thomas C R, Poolman Mark G, Fell David A, Ratcliffe R George, Sweetlove Lee J
Abstract excerpt
Flux balance models of metabolism generally utilize synthesis of biomass as the main determinant of intracellular fluxes. However, the biomass constraint alone is not sufficient to predict realistic fluxes in central heterotrophic metabolism of plant cells because of the major demand on the energy budget due to transport costs and cell maintenance. This major limitation can be addressed by incorporating transport...
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