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Article

Interaction of aryl hydrocarbon receptor-interacting protein-like 1 with the farnesyl moiety.

The Journal of biological chemistry - 19 Jul 2013

Majumder Anurima, Gopalakrishna Kota N, Cheguru Pallavi, Gakhar Lokesh, Artemyev Nikolai O

Abstract excerpt

Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) is a photoreceptor specific chaperone of the visual effector enzyme phosphodiesterase-6 (PDE6). AIPL1 has been shown to bind the farnesylated PDE6A subunit. Mutations in AIPL1 are thought to destabilize PDE6 and thereby cause Leber congenital amaurosis type 4 (LCA4), a severe form of childhood blindness. Here, we examined the solution structure of AIPL1...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23737531
DOI: 10.1074/jbc.M113.476242
PMCID: PMC3774400

Genes

AIPL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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