Article
Isaac: ultra-fast whole-genome secondary analysis on Illumina sequencing platforms.
Bioinformatics (Oxford, England) - 15 Aug 2013
Raczy Come, Petrovski Roman, Saunders Christopher T, Chorny Ilya, Kruglyak Semyon, Margulies Elliott H, Chuang Han-Yu, Källberg Morten, Kumar Swathi A, Liao Arnold, Little Kristina M, Strömberg Michael P, Tanner Stephen W
Abstract excerpt
SUMMARY: An ultrafast DNA sequence aligner (Isaac Genome Alignment Software) that takes advantage of high-memory hardware (>48 GB) and variant caller (Isaac Variant Caller) have been developed. We demonstrate that our combined pipeline (Isaac) is four to five times faster than BWA + GATK on equivalent hardware, with comparable accuracy as measured by trio conflict rates and sensitivity. We further show that Isaac...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.