Article
Angiotensinogen promoter polymorphisms predict low diffusing capacity in U.S. and Spanish IPF cohorts.
Lung - 1 Aug 2013
Dang My-Trang T, Gu Chenyang, Klavanian Jeannie I, Jernigan Katherine A, Friderici Karen H, Cui Yuehua, Molina-Molina Maria, Ancochea Julio, Xaubet Antoni, Uhal Bruce D
Abstract excerpt
BACKGROUND: Single nucleotide polymorphisms (SNPs) in angiotensinogen (AGT) at positions -20 and -6 are associated with increased severity and progression of various fibrotic diseases. Our earlier work demonstrated that the progression of idiopathic pulmonary fibrosis (IPF) was associated with the A-6 allele. This study examined the hypothesis that the homozygous CC genotype at -20 and the AA genotype at -6 would...
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