Article
Expression of PTEN in mycosis fungoides and correlation with loss of heterozygosity.
The American Journal of dermatopathology - 1 Jul 2013
Katona Terrence M, Smoller Bruce R, Webb Alden L, Hattab Eyas M, Khalil Ahmed, Hiatt Kim M
Abstract excerpt
BACKGROUND: Mycosis fungoides (MF) exhibits a variety of underlying molecular defects including aberrations involving the PTEN tumor suppressor gene. Specifically, loss of heterozygosity of PTEN has been previously demonstrated. We hypothesize that abnormalities of PTEN may result in altered immunohistochemical expression of its protein product. METHODS: Thirty-six MF specimens were stained with monoclonal...
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