Identification of alterations in the Jacobian of biochemical reaction networks from steady state covariance data at two conditions.

Abstract excerpt

Model building of biochemical reaction networks typically involves experiments in which changes in the behavior due to natural or experimental perturbations are observed. Computational models of reaction networks are also used in a systems biology approach to study how transitions from a healthy to a diseased state result from changes in genetic or environmental conditions. In this paper we consider the nonlinear...

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