Article
Dopamine from the brain promotes spinal motor neuron generation during development and adult regeneration.
Developmental cell - 10 Jun 2013
Reimer Michell M, Norris Anneliese, Ohnmacht Jochen, Patani Rickie, Zhong Zhen, Dias Tatyana B, Kuscha Veronika, Scott Angela L, Chen Yu-Chia, Rozov Stanislav, Frazer Sarah L, Wyatt Cameron, Higashijima Shin-ichi, Patton E Elizabeth, Panula Pertti, Chandran Siddharthan, Becker Thomas, Becker Catherina G
Abstract excerpt
Coordinated development of brain stem and spinal target neurons is pivotal for the emergence of a precisely functioning locomotor system. Signals that match the development of these far-apart regions of the central nervous system may be redeployed during spinal cord regeneration. Here we show that descending dopaminergic projections from the brain promote motor neuron generation at the expense of V2 interneurons...
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