Article
Molecular characterization of calcineurin B from the non-virulent Trypanosoma rangeli kinetoplastid indicates high gene conservation.
Molecular biology reports - 1 Aug 2013
Montenegro M, Cardenas C, Cuervo C, Bernal C, Grisard E C, Thomas M C, Lopez M C, Puerta C J
Abstract excerpt
Calcineurin B, the regulatory subunit of calcineurin, a serine/threonine protein phosphatase, is highly conserved throughout the evolutionary scale including trypanosomatids such as Trypanosoma cruzi, and Leishmania major. Thus, in these flagellates the protein is required for mammalian host cell invasion and virulence and stress responses. With the aim of determining the presence of calcineurin B in Trypanosoma...
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