Article
Single nucleotide polymorphisms in the upstream regulatory region alter the expression of myostatin.
In vitro cellular & developmental biology. Animal - 1 Jun 2013
Hu Wei, Chen Songyu, Zhang Ran, Lin Yushuang
Abstract excerpt
The expression of the gene encoding myostatin (MSTN), the product of which is a negative regulator of skeletal muscle growth and development in mammals, is regulated by many cis-regulatory elements, including enhancer box (E-box) motifs. While E-box motif mutants of MSTN exhibit altered expression of myostatin in many animal models, the phenotypes of these mutations in chicken are not investigated. In this study,...
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