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Article

Single-molecule study of the CUG repeat–MBNL1 interaction and its inhibition by small molecules

9 May 2013

Abstract excerpt

Effective drug discovery and optimization can be accelerated by techniques capable of deconvoluting the complexities often present in targeted biological systems. We report a single-molecule approach to study the binding of an alternative splicing regulator, muscleblind-like 1 protein (MBNL1), to (CUG)n = 4,6 and the effect of small molecules on this interaction. Expanded CUG repeats (CUG(exp)) are the causative...

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PMID: 23661680
DOI: 10.1093/nar/gkt330

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