Article
Identification of metabolic pathways influenced by the G-protein coupled receptors GprB and GprD in Aspergillus nidulans.
PloS one - 1 Jan 2013
de Souza Wagner R, Morais Enyara Rezende, Krohn Nadia Graciele, Savoldi Marcela, Goldman Maria Helena S, Rodrigues Fernando, Caldana Camila, Semelka Charles T, Tikunov Andrey P, Macdonald Jeffrey M, Goldman Gustavo Henrique
Abstract excerpt
Heterotrimeric G-protein-mediated signaling pathways play a pivotal role in transmembrane signaling in eukaryotes. Our main aim was to identify signaling pathways regulated by A. nidulans GprB and GprD G-protein coupled receptors (GPCRs). When these two null mutant strains were compared to the wild-type strain, the ΔgprB mutant showed an increased protein kinase A (PKA) activity while growing in glucose 1% and...
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