Article
Single-domain amnestic mild cognitive impairment identified by cluster analysis predicts Alzheimer's disease in the european prospective DESCRIPA study.
Dementia and geriatric cognitive disorders - 1 Jan 2013
Damian Marinella, Hausner Lucrezia, Jekel Katrin, Richter Melany, Froelich Lutz, Almkvist Ove, Boada Merce, Bullock Roger, De Deyn Peter Paul, Frisoni Giovanni B, Hampel Harald, Jones Roy W, Kehoe Patrick, Lenoir Hermine, Minthon Lennart, Olde Rikkert Marcel G M, Rodriguez Guido, Scheltens Philip, Soininen Hilkka, Spiru Luiza, Touchon Jacques, Tsolaki Magda, Vellas Bruno, Verhey Frans R J, Winblad Bengt, Wahlund Lars-Olof, Wilcock Gordon, Visser Pieter Jelle
Abstract excerpt
BACKGROUND/AIMS: To identify prodromal Alzheimer's disease (AD) subjects using a data-driven approach to determine cognitive profiles in mild cognitive impairment (MCI). METHODS: A total of 881 MCI subjects were recruited from 20 memory clinics and followed for up to 5 years. Outcome measures included cognitive variables, conversion to AD, and biomarkers (e.g. CSF, and MRI markers). Two hierarchical cluster...
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