Article
Clonality analysis suggests that STK11 gene mutations are involved in progression of lobular endocervical glandular hyperplasia (LEGH) to minimal deviation adenocarcinoma (MDA).
Virchows Archiv : an international journal of pathology - 1 Jun 2013
Takatsu Akiko, Miyamoto Tsutomu, Fuseya Chiho, Suzuki Akihisa, Kashima Hiroyasu, Horiuchi Akiko, Ishii Keiko, Shiozawa Tanri
Abstract excerpt
Lobular endocervical glandular hyperplasia (LEGH) is a benign proliferative disease of cervical glands. Although histological resemblance of minimal deviation adenocarcinoma (MDA) to LEGH and frequent association of LEGH with MDA have been reported, it still remains unclear whether LEGH is a precancerous lesion of MDA. The present study was undertaken to examine the pathogenetic relationship between LEGH and MDA...
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