[Cystic fibrosis: a gene at the end of the road].

Abstract excerpt

The authors first give an account of the work undertaken jointly by two Canadian and one American groups, which lead to the cloning and identification of the cystic fibrosis gene. To achieve this aim, it was necessary to clone a large region amounting to 500 kb, using chromosome walking and jumping. The gene was located from a cross-hybridization signal with two probes from the cloned region and bovine cDNA. The...

Topics

• Chromosome Mapping
• Cystic Fibrosis
• Female
• Genes
• Humans
• Mutation
• Pregnancy
• Prenatal Diagnosis