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An assessment of the genetic toxicology of novel boron‐containing therapeutic agents

26 Apr 2013

Abstract excerpt

Boron-containing compounds are being studied as potential therapeutic agents. As part of the safety assessment of these therapeutic agents, a battery of genetic toxicology studies was conducted. The battery included a bacterial reverse mutation (Ames) assay, an in vitro chromosome aberration assay in peripheral human lymphocytes, and an in vivo rat micronucleus study. The following compounds represent some of the...

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PMID: 23625818
DOI: 10.1002/em.21779

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