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Article

Cystic fibrosis transmembrane conductance regulator (CFTR) allelic variants relate to shifts in faecal microbiota of cystic fibrosis patients.

PloS one - 1 Jan 2013

Schippa Serena, Iebba Valerio, Santangelo Floriana, Gagliardi Antonella, De Biase Riccardo Valerio, Stamato Antonella, Bertasi Serenella, Lucarelli Marco, Conte Maria Pia, Quattrucci Serena

Abstract excerpt

INTRODUCTION: In this study we investigated the effects of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene variants on the composition of faecal microbiota, in patients affected by Cystic Fibrosis (CF). CFTR mutations (F508del is the most common) lead to a decreased secretion of chloride/water, and to mucus sticky secretions, in pancreas, respiratory and gastrointestinal tracts. Intestinal...

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Identifiers

PMID: 23613805
DOI: 10.1371/journal.pone.0061176
PMCID: PMC3629184

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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